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Total 7677 results found since Jan 2013.
Detection and verification of 2.3 million cancer mutations in NCI60 cancer cell lines with a cloud search engine.
We present and examine the abilities of Bolt, a new cloud-based proteomics search engine to search for the presence of over 2.3 million known cancer mutations in a matter of minutes while still performing a standard proteomics search that includes 31 post translational modifications. We use previously published proteomics data sets and identify mutations that are verified using genomic studies as well as previous proteomics efforts. Our results also emphasize the need to search for mutations in a comprehensive manner while still searching for both common and rare PTMs. SIGNIFICANCE: We present and examine the abilities of ...
Source: Journal of Proteomics - August 20, 2019 Category: Biochemistry Authors: Prakash A, Majumder S, Ahmad S, Varkey M, Anish TA, Jenkins C, Rigby M, Orsburn B Tags: J Proteomics Source Type: research
Bad news: The influence of news coverage and Google searches on Gardasil adverse event reporting.
CONCLUSION: The results suggest that some of the adverse events reported were not related to the vaccination itself, but to news coverage and internet search volumes, which may have contributed to public concerns about potentially unpleasant or harmful outcomes. These findings have implications for the importance of psychological and social factors in adverse event reporting, and the role of the news media in disseminating health information.
PMID: 29128382 [PubMed - as supplied by publisher]
Source: Vaccine - November 8, 2017 Category: Allergy & Immunology Authors: Faasse K, Porsius JT, Faasse J, Martin LR Tags: Vaccine Source Type: research
Adoptive T-cell Transfer Therapy and Oncogene-Targeted Therapy for Melanoma: The Search for Synergy.
Abstract
The clinical strengths of immunotherapy and small-molecule inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway appear to be largely complementary for the treatment of advanced melanoma. In current practice, most patients with BRAF V600 mutant melanomas will see both modalities. Several in vitro and in vivo studies suggest that combining immunotherapy with MAPK inhibition may have synergistic effects. First, mouse models show that adoptive cell therapy (ACT) can be enhanced by vaccination. Rapid tumor destruction by vemurafenib could provide a vaccine-like stimulus to adoptively transf...
Source: Clinical Cancer Research - October 1, 2013 Category: Cancer & Oncology Authors: Kwong ML, Neyns B, Yang JC Tags: Clin Cancer Res Source Type: research
Abstract IA07: In search of racial disparities in HPV vaccination
Background: Racial disparities in cervical cancer deaths are longstanding, with African American and Latina women more likely to die from the disease. The advent of HPV vaccine created an opportunity to reduce or end these disparities, but only if uptake was either uniformly high across all females or higher among minority than non-minority females. Thus, interest in racial disparities in HPV vaccine coverage has been understandably high.Findings: Data from several sources show racial disparities and "reverse disparities" in HPV vaccination coverage. First, the most reliable national data are from the National Immunization...
Source: Cancer Epidemiology Biomarkers and Prevention - September 30, 2015 Category: Cancer & Oncology Authors: Brewer, N. T., Moss, J. L., Reiter, P. L. Tags: Vaccines and Immunoprevention: Oral Presentations - Invited Abstracts Source Type: research
Cancers, Vol. 10, Pages 492: Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
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To date, no targeted drugs, antibodies or combinations of chemotherapeutics have been demonstrated to be more efficient than temozolomide, or to increase efficacy of standard therapy (surgery, radiotherapy, temozolomide, steroid dexamethasone). According to recent phase III trials, standard therapy may ensure a median overall survival of up to 18–20 months for adult patients with newly diagnosed glioblastoma. These data explain a failure of positive non-controlled phase II trials to predict positive phase III trials and should result in revision of the landmark Stupp trial as a historical control for ...
Source: Cancers - December 5, 2018 Category: Cancer & Oncology Authors: Aleksei A. Stepanenko Vladimir P. Chekhonin Tags: Review Source Type: research
Cancers, Vol. 14, Pages 4191: Cancerous Tumor Controlled Treatment Using Search Heuristic (GA)-Based Sliding Mode and Synergetic Controller
ad Fazal Ijaz
Cancerous tumor cells divide uncontrollably, which results in either tumor or harm to the immune system of the body. Due to the destructive effects of chemotherapy, optimal medications are needed. Therefore, possible treatment methods should be controlled to maintain the constant/continuous dose for affecting the spreading of cancerous tumor cells. Rapid growth of cells is classified into primary and secondary types. In giving a proper response, the immune system plays an important role. This is considered a natural process while fighting against tumors. In recent days, achieving a better method to treat ...
Source: Cancers - August 29, 2022 Category: Cancer & Oncology Authors: Fazal Subhan Muhammad Adnan Aziz Inam Ullah Khan Muhammad Fayaz Marcin Wozniak Jana Shafi Muhammad Fazal Ijaz Tags: Article Source Type: research
Strange results
Discussion PaperBritish Guideline on the management of asthmaDeveloping and Evaluating Methods for Record Linkage and Reducing Bias in Patient RegistriesNow, these are not specifically about immunisations but they'll all make reference to it. For instance the top result has the following:Vaccinations1.4.2 Be aware that live vaccinations may be contraindicated in people with MS who are being treated with disease-modifying therapies.We return all the results that match the search terms (and/or synonyms). However, our algorithm is designed to emphasise those results which are more relevant. So, ordinarily, i...
Source: Liberating the literature - October 31, 2014 Category: Technology Consultants Source Type: blogs
Top 10 Online Medical Resources For The Patients Of The Future
There are over 1 billion health-related searches on Google every single day, according to a report. This was about 7% of all searches on the platform before, and no one will be surprised when the 2020 data massively surpasses this number. After all, the internet is likely the first source to turn to with your health-related questions.
But which hits are relevant, and which lead to straightforward la la land – even with the best intentions and the best A.I. toolset, the search giant can’t exclude the latter from among the results. And yet, doing so is especially important in the case of medicine and healthcare, s...
Source: The Medical Futurist - December 10, 2020 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research E-Patients Medical Education Medicine social media Webicina webmd gc2 online resources pharmaceutics Topol Mayo Clinic ePatients Medscape Eric Topol Smart Patients Medline Plus National Library of Source Type: blogs
The Effectiveness of Disaster Risk Communication: A Systematic Review of Intervention Studies
The objectives of the interventions were to improve the health knowledge and behaviour in relation to disasters, and to decrease the incidence of negative health events. The studies were chosen on that basis, and several studies reported additional outcomes that were outside the scope of this review. The knowledge, behaviour and incidence outcomes are described in detail in Appendix 3 (characteristics and results of included studies).
Results of Individual Studies
1 Effect of Risk Communication Interventions to Promote Disaster Mitigation and Preparedness
1.1 Communication to Promote Mitigation and Preparedness for Infec...
Source: PLOS Currents Disasters - August 22, 2014 Category: Global & Universal Authors: dtbradley Source Type: research
Integrated Multi-omics, Virtual Screening and Molecular Docking Analysis of Methicillin-Resistant < em > Staphylococcus aureus < /em > USA300 for the Identification of Potential Therapeutic Targets: An In-Silico Approach
In this study, staphylococcal FemA protein (P0A0A5) is subjected to structure-based virtual screening for the drug repurposing approach. There are 20 residues missing in the crystal structure of FemA, and 12 of these residues are located at the catalytic site. The missing residues are modelled, and stereochemistry is checked. FDA approved drugs available in the DrugBank database have been used in virtual screening with FemA in search of potential repurposed molecules. This approach provides us with 10 drugs that may be used in the treatment of methicillin-resistant staphylococcal mediated diseases. AutoDock 4.2 is used for...
Source: Cell Research - September 22, 2021 Category: Cytology Authors: Shakilur Rahman Amit Kumar Das Source Type: research
A systematic review and meta-analysis of immune response against first and second doses of SARS-CoV-2 vaccines in adult patients with hematological malignancies
CONCLUSION: Our findings highlight the substantially low rate of seroprotection in patients with hematological malignancies with a wide range of rates among disease subgroups and different treatments; further highlighting the fact that booster doses might be acquired for these patients to improve immunity against SARS-CoV-2.PMID:35843148 | PMC:PMC9273573 | DOI:10.1016/j.intimp.2022.109046
Source: International Immunopharmacology - July 17, 2022 Category: Allergy & Immunology Authors: Maryam Noori Shadi Azizi Farhan Abbasi Varaki Seyed Aria Nejadghaderi Davood Bashash Source Type: research
Fight Aging! Newsletter, April 2nd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - April 1, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Factors Associated With African American Mothers' Perceptions of Human Papillomavirus Vaccination of Their Daughters: An Integrated Literature Review
Oncol Nurs Forum. 2021 Jul 1;48(4):371-389. doi: 10.1188/21.ONF.371-389.ABSTRACTPROBLEM IDENTIFICATION: African American (AA) women have a higher mortality rate for cervical and other cancers and are less likely to have received the human papillomavirus (HPV) vaccine than White women. Mothers play a significant family role and have a unique relationship with their daughters. Mothers' positive views on HPV vaccination may enhance the HPV vaccination rate among their daughters.LITERATURE SEARCH: The review was conducted by searching literature in PubMed®, CINAHL®, ScienceDirect, Ovid MEDLINE®, and ProQuest databases. The ...
Source: Oncology Nursing Forum - June 18, 2021 Category: Nursing Authors: Stella Dike Wyona M Freysteinson Source Type: research
